Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.Estelles A., J. Biol. Chem. 271:14800-14806(1996)Condorelli G., EMBO J. 17:3858-3866(1998)Wolford J.K., Gene 241:143-148(2000)
应用类型
WB,IHC
免疫原
Peptide sequence around phosphorylation site of Serine 104(I-P-S(p)-A-K) derived from Human PEA-15.
