Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.Martin Oppermann, J. Biol. Chem., Mar 1999; 274: 8875Beatrix Pollok-Kopp, J. Biol. Chem., Jan 2003; 278: 2190 - 2198Ramtin Rahbar, J. Virol., Jul 2006; 80: 7245 - 7259H Olbrich, J. Leukoc. Biol., Mar 1999; 65: 281
应用类型
WB
免疫原
Peptide sequence around phosphorylation site of Serine 349 (E-I-S(p)-V-G) derived from Human CCR5.
