Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
应用类型
WB,IHC
免疫原
Peptide sequence around phosphorylation site of serine 142(D-L-S(p)-S-D) derived from Human CREB.
