This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
应用类型
WB,IHC
免疫原
Peptide sequence around phosphorylation site of serine 129 (I-L-S(p)-R-R) derived from Human CREB.
