Sclerostin is a secreted glycoprotein with a C-terminalncysteine knot-like (CTCK) domain and sequence similarity to the DANn(differential screening-selected gene aberrative in neuroblastoma)nfamily of bone morphogenetic protein (BMP) antagonists.nLoss-of-function mutations in this gene are associated with annautosomal-recessive disorder, sclerosteosis, which causesnprogressive bone overgrowth. A deletion downstream of this gene,nwhich causes reduced sclerostin expression, is associated with anmilder form of the disorder called van Buchem disease. [provided bynRefSeq].
应用类型
WB
免疫原
This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.
