Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
应用类型
WB
免疫原
This INTS6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 135-167 amino acids from human INTS6.
