HIV-1, the causative agent of acquired immunodeficiencynsyndrome (AIDS), contains an RNA genome that produces anchromosomally integrated DNA during the replicative cycle.nActivation of HIV-1 gene expression by the transactivator Tat isndependent on an RNA regulatory element (TAR) located downstream ofnthe transcription initiation site. The protein encoded by this genenis a transcriptional repressor that binds to chromosomallynintegrated TAR DNA and represses HIV-1 transcription. In addition,nthis protein regulates alternate splicing of the CFTR gene. Ansimilar pseudogene is present on chromosome 20. [provided bynRefSeq].
应用类型
WB,IHC
免疫原
This TARDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TARDBP.
