ALOXE3 is a member of the lipoxygenase family, whichnare catabolized by arachidonic acid-derived compounds. The encodednenzyme is a hydroperoxide isomerase that synthesizes a unique typenof epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoicnacid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). Thisnepoxy alcohol can activate the the nuclear receptor peroxisomenproliferator-activated receptor alpha (PPARalpha), which isnimplicated in epidermal differentiation. Loss of function of thenenzyme encoded by this gene results in ichthyosis, implicating thenfunction of this gene in the differentiation of human skin.
应用类型
WB,IHC
免疫原
This ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human ALOXE3.
