HLA-DPB belongs to the HLA class II beta chain paralogues.nThis class II molecule is a heterodimer consisting of an alphan(DPA) and a beta chain (DPB), both anchored in the membrane. Itnplays a central role in the immune system by presenting peptidesnderived from extracellular proteins. Class II molecules arenexpressed in antigen presenting cells (APC: B lymphocytes,ndendritic cells, macrophages). The beta chain is approximatelyn26-28 kDa and its gene contains 6 exons. Exon one encodes thenleader peptide, exons 2 and 3 encode the two extracellular domains,nexon 4 encodes the transmembrane domain and exon 5 encodes thencytoplasmic tail. Within the DP molecule both the alpha chain andnthe beta chain contain the polymorphisms specifying the peptidenbinding specificities, resulting in up to 4 different molecules.
应用类型
WB,IHC,FCM
免疫原
This HLA-DPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the Central region of human HLA-DPB1.
