Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
应用类型
WB
免疫原
This TPX2 antibody is generated from a mouse immunized with a recombinant protein between 1-531 amino acids from the human TPX2.
