The assembly and stability of the RNA polymerase IIntranscription pre-initiation complex on a eukaryotic core promoterninvolve the effects of TFIIA on the interaction betweennTATA-binding protein (TBP) and DNA. This gene encodes a germncell-specific counterpart of the large (alpha/beta) subunit ofngeneral transcription factor TFIIA that is able to stabilize thenbinding of TBP to DNA and may be uniquely important to testisnbiology. Alternative splicing for this locus has been observed andntwo variants, encoding distinct isoforms, have been identified.nCo-transcription of this gene and the neighboring upstream genengenerates a rare transcript (SALF), which encodes a fusion proteinncomprised of sequence sharing identity with each individual genenproduct.
应用类型
WB
免疫原
This GTF2A1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-428 amino acids from the C-terminal region of human GTF2A1L.
