Dentin matrix acidic phosphoprotein is an extracellularnmatrix protein and a member of the small integrin binding ligandnN-linked glycoprotein family. This protein, which is critical fornproper mineralization of bone and dentin, is present in diversencells of bone and tooth tissues. The protein contains a largennumber of acidic domains, multiple phosphorylation sites, anfunctional arg-gly-asp cell attachment sequence, and a DNA bindingndomain. In undifferentiated osteoblasts it is primarily a nuclearnprotein that regulates the expression of osteoblast-specific genes.nDuring osteoblast maturation the protein becomes phosphorylated andnis exported to the extracellular matrix, where it orchestratesnmineralized matrix formation. Mutations in the gene are known toncause autosomal recessive hypophosphatemia, a disease thatnmanifests as rickets and osteomalacia. The gene structure isnconserved in mammals. Two transcript variants encoding differentnisoforms have been described for this gene.
应用类型
WB
免疫原
This DMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-175 amino acids from the N-terminal region of human DMP1.
