This gene encodes a member of the semaphorin family ofnsoluble and transmembrane proteins. Semaphorins are involved innnumerous functions, including axon guidance, morphogenesis,ncarcinogenesis, and immunomodulation. The encoded protein is ansingle-pass type I membrane protein containing annimmunoglobulin-like C2-type domain, a PSI domain and a sema domain.nIt inhibits axonal extension by providing local signals to specifynterritories inaccessible for growing axons. It is an activator ofnT-cell-mediated immunity and suppresses vascular endothelial growthnfactor (VEGF)-mediated endothelial cell migration and proliferationnin vitro and angiogenesis in vivo. Mutations in this gene arenassociated with retinal degenerative diseases including retinitisnpigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10).nMultiple alternatively spliced transcript variants encodingndifferent isoforms have been identified.
应用类型
WB
免疫原
This SEMA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human SEMA4A.
