Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
应用类型
WB
免疫原
This PHC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 308-342 amino acids from human PHC1.
