Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).
应用类型
WB
免疫原
This NACA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 36-69 amino acids from human NACA2.
