Lysyl hydroxylase is a membrane-bound homodimeric proteinnlocalized to the cisternae of the endoplasmic reticulum. The enzymen(cofactors iron and ascorbate) catalyzes the hydroxylation of lysylnresidues in collagen-like peptides. The resultant hydroxylysylngroups are attachment sites for carbohydrates in collagen and thusnare critical for the stability of intermolecular crosslinks. Somenpatients with Ehlers-Danlos syndrome type VI have deficiencies innlysyl hydroxylase activity.
应用类型
WB,IHC,FCM
免疫原
This PLOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human PLOD1.
