Involved in cell adhesion and probably in cell-cell interactions. nRegulates the migration of neural precursor cells. nReceptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. nBinding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. nIsoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. nOverexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.
应用类型
WB
免疫原
This antibody is generated from a mouse immunized with a recombinant protein.
