Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
应用类型
WB
免疫原
This Mouse Ihh antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 397-430 amino acids from the C-terminal region of mouse Ihh.
