Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
应用类型
WB
免疫原
This SMG7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 896-930 amino acids from the C-terminal region of human SMG7.
