Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
应用类型
WB
免疫原
This Mouse Frk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 482-516 amino acids from the C-terminal region of human Mouse Frk.
