The protein encoded by this gene is a member of thenthree-amino acid loop extension (TALE) superclass of atypicalnhomeodomains. TALE homeobox proteins are highly conservedntranscription regulators. This particular homeodomain binds to anpreviously characterized retinoid X receptor responsive elementnfrom the cellular retinol-binding protein II promoter. In additionnto its role in inhibiting 9-cis-retinoic acid-dependent RXR alphantranscription activation of the retinoic acid responsive element,nthe protein is an active transcriptional co-repressor of SMAD2 andnmay participate in the transmission of nuclear signals duringndevelopment and in the adult. Mutations in this gene are associatednwith holoprosencephaly type 4, which is a structural anomaly of thenbrain. Alternative splicing has been observed at this locus andneight variants, encoding four distinct isoforms, are described.
应用类型
WB
免疫原
This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human TGIF1.
