The protein encoded by this gene belongs to thenubiquitin-conjugating enzyme family. This protein interacts withnRING finger proteins, and it can ubiquitinate huntingtin, the genenproduct for Huntington's disease. Known functions for this proteinninclude a role in aggregate formation of expanded polyglutaminenproteins and the suppression of apoptosis in polyglutaminendiseases, a role in the dislocation of newly synthesized MHC classnI heavy chains from the endoplasmic reticulum, and involvement innfoam cell formation. Multiple transcript variants encodingndifferent isoforms have been identified for this gene. [provided bynRefSeq].
应用类型
WB
免疫原
This UBE2K antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human UBE2K.
