C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
应用类型
WB
免疫原
This C1QA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 89-103 amino acids from the Central region of human C1QA.
