External and internal DNA-damaging agents continuallynthreaten the integrity of genetic material in cells. Although anvariety of repair mechanisms exist to remove the resulting lesions,nsome lesions escape repair and block the replication machinery.nMembers of the Y family of DNA polymerases, such as POLK, permitnthe continuity of the replication fork by allowing replicationnthrough such DNA lesions. Each Y family polymerase has a uniquenDNA-damage bypass and fidelity profile. POLK is specialized for thenextension step of lesion bypass (summary by Lone et al., 2007n[PubMed 17317631]).
应用类型
WB
免疫原
This POLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the Central region of human POLK.
