The 26S proteasome is a multicatalytic proteinase complexnwith a highly ordered structure composed of 2 complexes, a 20S corenand a 19S regulator. The 20S core is composed of 4 rings of 28nnon-identical subunits; 2 rings are composed of 7 alpha subunitsnand 2 rings are composed of 7 beta subunits. The 19S regulator isncomposed of a base, which contains 6 ATPase subunits and 2nnon-ATPase subunits, and a lid, which contains up to 10 non-ATPasensubunits. Proteasomes are distributed throughout eukaryotic cellsnat a high concentration and cleave peptides in annATP/ubiquitin-dependent process in a non-lysosomal pathway. Annessential function of a modified proteasome, the immunoproteasome,nis the processing of class I MHC peptides. This gene encodes annon-ATPase subunit of the 19S regulator base.
应用类型
WB
免疫原
This PSMD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-457 amino acids from the C-terminal region of human PSMD5.
