Histones are basic nuclear proteins that are responsiblenfor the nucleosome structure of the chromosomal fiber inneukaryotes. This structure consists of approximately 146 bp of DNAnwrapped around a nucleosome, an octamer composed of pairs of eachnof the four core histones (H2A, H2B, H3, and H4). The chromatinnfiber is further compacted through the interaction of a linkernhistone, H1, with the DNA between the nucleosomes to form highernorder chromatin structures. This gene is intronless and encodes anmember of the histone H3 family. Transcripts from this gene lacknpolyA tails; instead, they contain a palindromic terminationnelement. This gene is found in a histone cluster on chromosome 1.nThis gene is one of four histone genes in the cluster that arenduplicated; this record represents the telomeric copy. [provided bynRefSeq].
应用类型
WB
免疫原
This HIST2H3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-136 amino acids from the C-terminal region of human HIST2H3A.
