This gene encodes a member of the CD1 family ofntransmembrane glycoproteins, which are structurally related to thenmajor histocompatibility complex (MHC) proteins and formnheterodimers with beta-2-microglobulin. The CD1 proteins mediatenthe presentation of primarily lipid and glycolipid antigens of selfnor microbial origin to T cells. The human genome contains five CD1nfamily genes organized in a cluster on chromosome 1. The CD1 familynmembers are thought to differ in their cellular localization andnspecificity for particular lipid ligands. The protein encoded bynthis gene localizes to late endosomes and lysosomes via antyrosine-based motif in the cytoplasmic tail, and requiresnvesicular acidification to bind lipid antigens. [provided bynRefSeq].
应用类型
WB
免疫原
This CD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human CD1B.
