CDC42, a small Rho GTPase, regulates the formation ofnF-actin-containing structures through its interaction with thendownstream effector proteins. The protein encoded by this gene is anmember of the Borg family of CDC42 effector proteins. Borg familynproteins contain a CRIB (Cdc42/Rac interactive-binding) domain.nThey bind to, and negatively regulate the function of, CDC42.nCoexpression of this protein with dominant negative mutant CDC42nprotein in fibroblast was found to induce pseudopodia formation,nwhich suggested a role of this protein in actin filament assemblynand cell shape control.
应用类型
WB
免疫原
This CDC42EP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human CDC42EP2.
