The product of this gene belongs to the family ofnpurinoceptors for ATP. This receptor functions as a ligand-gatednion channel with relatively high calcium permeability. Binding tonATP mediates synaptic transmission between neurons and from neuronsnto smooth muscle, being responsible, for example, for sympatheticnvasoconstriction in small arteries, arterioles and vas deferens.nMouse studies suggest that this receptor is essential for normalnmale reproductive function. It is possible that the development ofnselective antagonists for this receptor may provide an effectivennon-hormonal male contraceptive pill.
应用类型
WB
免疫原
This P2RX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-372 amino acids from the C-terminal region of human P2RX1.
