In mammals, histamine is metabolized by two majornpathways: N(tau)-methylation via histamine N-methyltransferase andnoxidative deamination via diamine oxidase. This gene encodes thenfirst enzyme which is found in the cytosol and usesnS-adenosyl-L-methionine as the methyl donor. In the mammaliannbrain, the neurotransmitter activity of histamine is controlled bynN(tau)-methylation as diamine oxidase is not found in the centralnnervous system. A common genetic polymorphism affects the activitynlevels of this gene product in red blood cells. Multiplenalternatively spliced transcript variants that encode differentnproteins have been found for this gene.
应用类型
WB
免疫原
Purified His-tagged HNMT protein(Fragment) was used to produced this monoclonal antibody.
