Rho GTPases play a fundamental role in numerous cellularnprocesses that are initiated by extracellular stimuli that worknthrough G protein coupled receptors. The encoded protein belongs tona family of cytoplasmic proteins that activate the Ras-like familynof Rho proteins by exchanging bound GDP for GTP. It may form ancomplex with G proteins and stimulate Rho-dependent signals. Thisnprotein is activated by PI3-kinase. Mutations in this gene canncause X-chromosomal non-specific mental retardation. [provided bynRefSeq].
应用类型
WB
免疫原
This ARHGEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-641 amino acids from the C-terminal region of human ARHGEF6.
