The protein encoded by this gene is a member of the folatenreceptor (FOLR) family, and these genes exist in a cluster onnchromosome 11. Members of this gene family have a high affinity fornfolic acid and for several reduced folic acid derivatives, and theynmediate delivery of 5-methyltetrahydrofolate to the interior ofncells. This protein has a 68% and 79% sequence homology with thenFOLR1 and FOLR3 proteins, respectively. Although this protein wasnoriginally thought to be specific to placenta, it can also exist innother tissues, and it may play a role in the transport ofnmethotrexate in synovial macrophages in rheumatoid arthritisnpatients. Multiple transcript variants that encode the same proteinnhave been found for this gene.
应用类型
WB
免疫原
This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human FOLR2.
