This gene encodes a secreted, homodimeric glycoproteinnthat is expressed in a wide variety of tissues and may havenautocrine or paracrine functions. The gene contains a 5' UTR richnin CAG trinucleotide repeats. The encoded protein contains 11nconserved cysteine residues and is phosphorylated by protein kinasenC exclusively on its serine residues. The protein may play a rolenin the regulation of renal and intestinal calcium and phosphatentransport, cell metabolism, or cellular calcium/phosphatenhomeostasis. Overexpression of human stanniocalcin 1 in micenproduces high serum phosphate levels, dwarfism, and increasednmetabolic rate. This gene has altered expression in hepatocellular,novarian, and breast cancers.
应用类型
WB
免疫原
This STC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-221 amino acids from the C-terminal region of human STC1.
