This gene encodes a secreted, homodimeric glycoproteinnthat is expressed in a wide variety of tissues and may havenautocrine or paracrine functions. The encoded protein has 10 of itsn15 cysteine residues conserved among stanniocalcin family membersnand is phosphorylated by casein kinase 2 exclusively on its serinenresidues. Its C-terminus contains a cluster of histidine residuesnwhich may interact with metal ions. The protein may play a role innthe regulation of renal and intestinal calcium and phosphatentransport, cell metabolism, or cellular calcium/phosphatenhomeostasis. Constitutive overexpression of human stanniocalcin 2nin mice resulted in pre- and postnatal growth restriction, reducednbone and skeletal muscle growth, and organomegaly. Expression ofnthis gene is induced by estrogen and altered in some breastncancers.
应用类型
WB,IHC
免疫原
This STC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the C-terminal region of human STC2.
