The protein encoded this gene contains two RING-fingernmotifs and an IBR (in between RING fingers) motif. This protein isnan E3 ubiquintin ligase that is localized in Lewy bodies (LBs), ancharacteristic neuronal inclusion in Parkinson's disease (PD)nbrains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8,nbut not other ubiquitin-conjugating enzymes. This protein is foundnto bind and ubiquitylate synphilin 1 (SNCAIP), which is aninteracting protein of alpha synuclein in neurons, and a majorncomponent of LB. Alternatively spliced transcript variants encodingnthe same protein have been reported.
应用类型
WB,IHC
免疫原
This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.
