Chromosomal protein HMG14 and its close analog HMG17 (MIMn163910) bind to the inner side of the nucleosomal DNA, potentiallynaltering the interaction between the DNA and the histone octamer.nThe 2 proteins may be involved in the process that maintainsntranscribable genes in a unique chromatin conformation. Theirnubiquitous distribution and relative abundance, as well as the highnevolutionary conservation of the DNA-binding domain of the HMG14nfamily of proteins, suggest that they may be involved in annimportant cellular function.
应用类型
WB,IHC
免疫原
This HMGN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HMGN1.
