This gene encodes an immunoregulatory cytokine producednprimarily by activated Th2 cells. This cytokine is involved innseveral stages of B-cell maturation and differentiation. Itnup-regulates CD23 and MHC class II expression, and promotes IgEnisotype switching of B cells. This cytokine down-regulatesnmacrophage activity, thereby inhibits the production ofnpro-inflammatory cytokines and chemokines. This cytokine is foundnto be critical to the pathogenesis of allergen-induced asthma butnoperates through mechanisms independent of IgE and eosinophils.nThis gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster onnchromosome 5q, with this gene particularly close to IL4. [providednby RefSeq].
应用类型
WB,IHC,ICC
免疫原
This IL13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human IL13.
