This gene is a member of the DAZ gene family and is ancandidate for the human Y-chromosomal azoospermia factor (AZF). Itsnexpression is restricted to premeiotic germ cells, particularly innspermatogonia. It encodes an RNA-binding protein that is importantnfor spermatogenesis. Four copies of this gene are found onnchromosome Y within palindromic duplications; one pair of genes isnpart of the P2 palindrome and the second pair is part of the P1npalindrome. Each gene contains a 2.4 kb repeat including a 72-bpnexon, called the DAZ repeat; the number of DAZ repeats is variablenand there are several variations in the sequence of the DAZ repeat.nEach copy of the gene also contains a 10.8 kb region that may benamplified; this region includes five exons that encode an RNAnrecognition motif (RRM) domain. This gene contains one copy of then10.8 kb repeat. Alternative splicing results in multiple transcriptnvariants encoding different isoforms.
应用类型
WB
免疫原
This DAZ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-546 amino acids from the C-terminal region of human DAZ2.
