Histones are basic nuclear proteins that are responsiblenfor the nucleosome structure of the chromosomal fiber inneukaryotes. Nucleosomes consist of approximately 146 bp of DNAnwrapped around a histone octamer composed of pairs of each of thenfour core histones (H2A, H2B, H3, and H4). The chromatin fiber isnfurther compacted through the interaction of a linker histone, H1,nwith the DNA between the nucleosomes to form higher order chromatinnstructures. This gene is intronless and encodes a member of thenhistone H3 family. Transcripts from this gene lack polyA tails;ninstead, they contain a palindromic termination element. This genenis located separately from the other H3 genes that are in thenhistone gene cluster on chromosome 6p22-p21.3. [provided bynRefSeq].
应用类型
WB,FCM
免疫原
This HIST3H3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the Central region of human HIST3H3.
