The serine-threonine protein kinase encoded by the AKT1ngene is catalytically inactive in serum-starved primary andnimmortalized fibroblasts. AKT1 and the related AKT2 are activatednby platelet-derived growth factor. The activation is rapid andnspecific, and it is abrogated by mutations in the pleckstrinnhomology domain of AKT1. It was shown that the activation occursnthrough phosphatidylinositol 3-kinase. In the developing nervousnsystem AKT is a critical mediator of growth factor-induced neuronalnsurvival. Survival factors can suppress apoptosis in antranscription-independent manner by activating the serine/threoninenkinase AKT1, which then phosphorylates and inactivates componentsnof the apoptotic machinery. Multiple alternatively splicedntranscript variants have been found for this gene. [provided bynRefSeq].
应用类型
WB
免疫原
This AKT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T450 of human AKT1.
