This gene encodes a tetratricopeptide repeat-containingncomponent of the anaphase promoting complex/cyclosome (APC/C), anlarge E3 ubiquitin ligase that controls cell cycle progression byntargeting a number of cell cycle regulators such as B-type cyclinsnfor 26S proteasome-mediated degradation through ubiquitination. Thenencoded protein is required for the proper ubiquitination functionnof APC/C and for the interaction of APC/C with transcriptionncoactivators. It also interacts with polyA binding protein andnrepresses internal ribosome entry site-mediated translation.nMultiple transcript variants encoding different isoforms have beennfound for this gene. These differences cause translation initiationnat a downstream AUG and result in a shorter protein (isoform b),ncompared to isoform a.
应用类型
WB,FCM
免疫原
This ANAPC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ANAPC5.
