Gap junction gamma-3, also known as connexin-30.2 (Cx30.2) or connexin-31.3 (Cx31.3) or gap junction epsilon-1 (GJE1), is a protein that in humans is encoded by the GJC3 gene. GJC3 is a connexin. This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.