Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene. The gene is also known as KAIA0053. ARHGAP25 belongs to a family of Rho GTPase-modulating proteins which are implicated in actin remodeling, cell polarity, and cell migration. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.