This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1).
应用类型
WB,ICC,FCM
免疫原
Purified recombinant fragment of human MIB1 (AA: 6-221) expressed in E. Coli.
