This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factorr family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factorr bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composedr of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene playsr a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associatedr with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a varietyr of other cancers.
应用类型
ICC
免疫原
Purified recombinant fragment of human PDGFRA (AA: 361-528) expressed in E. Coli.
