This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
应用类型
IHC,FCM
免疫原
Purified recombinant fragment of human KLF1 (AA: 208-362) expressed in E. Coli.
