CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide nbonds .It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells nleads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact nwith MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated nkilling. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine- nprotein kinase p56lck.
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Purified recombinant fragment of human CD8 expressed in E. Coli.
