ATF3 belongs to the mammalian activation transcription factor/cAMP responsive element-binding （CREB） protein family of transcription factors. ATF3 binds the cAMP response element （CRE） （consensus: 5’-GTGACGT[AC][AG]-3’）， a sequence present in numerous viral and cellular promoters. Multiple transcript variants encoding two different isoforms are known for this gene. The longer isoform represses transcription from promoters with ATF binding elements instead of activating it. The shorter isoform （deltaZip2） which stimulates transcription by sequestering inhibitory co-factors away from the promoter has no leucine zipper protein-dimerization motif and does not bind to DNA.
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大肠杆菌中重组表达.
溶解建议
提供的重组人活化转录因子3产品形式为无菌的澄清溶液.
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建议将重组人活化转录因子3产品整瓶保存于4℃可保存2-4周. 长期保存，请置于-20℃.长期保存，推荐添加载体蛋白 （0.1% HSA or BSA）.请避免反复冻融.
