TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人硫嘌呤甲基转移酶(TPMT)产品为过滤灭菌的无色溶液;其中1mg/ml人硫嘌呤甲基转移酶(TPMT)产品溶解于20mM Tris 8.0,0.2mM PMSF,2mM EDTA溶液中.