Endothelial cells express three different vascular endothelial growth factor （VEGF） receptors， belonging to the family of receptor tyrosine kinases （RTKs）. They are named VEGFR-1 （Flt-1）， VEGFR-2 （KDR/Flk-1）， VEGFR-3 （Flt-4）. Their expression is almost exclusively restricted to endothelial cells， but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains， a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor， but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation.
Differential splicing of the flt-1 gene leads to the formation of a secreted， soluble variant of VEGFR-1 （sVEGFR-1）. No naturally occuring， secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
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昆虫细胞中重组表达
溶解建议
提供的人血管内皮生长因子受体-2（VEGFR2）产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1mg/ml人血管内皮生长因子受体-2（VEGFR2）的25mM MES pH 5.5，100mM NaCl溶液中过滤灭菌并冻干产生的.我们建议加无菌水以配制工作储存液到不低于100ug/ml，后继实验过程中可根据实验要求进一步稀释.
